Phosphopantetheine-binding protein

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August undefined, 2024

WebFeb 1, 2024 · The reaction mechanism of PPAT involves a nucleophilic attack by 4′-phosphate of phosphopantetheine on the α-phosphate of ATP in an in-line displacement mechanism, where both the substrates are positioned in a single line. This results in a short lived intermediate pentacovalent transition state. WebThe mitochondrial acyl carrier protein (human ACPM, yeast Acp1) is an essential mitochondrial protein. Through binding of nascent acyl chains on the serine (S112)-bound 4′-phosphopantetheine (4′-PP) cofactor, ACPM is involved in mitochondrial fatty acid synthesis and lipoic acid biogenesis. Recently, yeast A Molecular Pharmacology

Phosphopantetheine - an overview ScienceDirect Topics

WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl carrier proteins ... (for 4′-phosphopantetheine 10). The binding of dephospho-CoA was also shown to be competitive with both ATP and phosphopantetheine, whereas ... WebNov 13, 2013 · 4ihh: Chasing acyl carrier protein through a catalytic cycle of lipid A production. drywall repair contractor boulder co

Lipoate protein ligase B primarily recognizes the C8-phosphopantetheine …

WebJul 10, 2024 · ACP3 is a four-helix bundle with S38 being unmodified in the apo form of the protein, phosphopantheine bound in the holo form, and with polyketide substrate attached … WebThe acyl carrier protein ( ACP) is a cofactor of both fatty acid and polyketide biosynthesis machinery. It is one of the most abundant proteins in cells of E. coli. [1] In both cases, the … WebProtein Phosphopantetheine-binding Status UniProtKB unreviewed (TrEMBL) Organism Catenulispora acidiphila (strain DSM 44928 / JCM 14897 / NBRC 102108 / NRRL B-24433 / ID139908) Amino acids 92 Protein existence Predicted Annotation score 1/5 Entry Feature viewer Publications External links History BLAST Download Add Add a publication Entry … commerce tx post office

Type I pyridoxal 5′-phosphate dependent enzymatic domains …

Structure, function and dynamics in acyl carrier proteins

WebJul 1, 2003 · Phosphopantetheine adenylyltransferase (PPAT) regulates the key penultimate step in the essential coenzyme A (CoA) biosynthetic pathway. PPAT catalyzes the reversible transfer of an adenylyl group from Mg2+:ATP to 4′-phosphopantetheine to form 3′-dephospho-CoA (dPCoA) and pyrophosphate. WebOct 29, 2024 · The brain abnormalities are fully corrected at the level of gene expression, protein quantity, and enzyme activity following the oral administration of 4′-phosphopantetheine. These changes in gene expression represent a pharmacodynamic biomarker set that can serve for the preclinical development of PKAN therapeutics. commerce tx realtorsWebPhosphopantetheine-binding protein (Pectobacterium carotovorum PC1) - STRING interaction network Nodes: Network nodes represent proteins splice isoforms or post … drywall repair contractor atlanta

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Phosphopantetheine-binding protein

61012291 - Gene ResultWI98_RS26710 phosphopantetheine …

WebJun 6, 2024 · Unique CFP (cysteine-free protein; 120 aa) has been identified as an extraordinary virulence factor in Beauveria bassiana (Cordycipitaceae), a main source of wide-spectrum fungal insecticides. Its homologs exclusively exist in wide-spectrum insect pathogens of Hypocreales, suggesting their importance for a fungal insect-pathogenic … WebJan 3, 2024 · Using E. coli LipB as a prototype, we show that the enzyme mainly recognizes the 4’-phosphopantetheine tethered acyl-chain of its donor substrate, and weakly binds the apo-acyl carrier protein. It can accept octanoate-from its own ACP, noncognate ACPs, as well as C 8 -CoA.

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Phosphopantetheine, also known as 4'-phosphopantetheine, is a prosthetic group of several acyl carrier proteins including the acyl carrier proteins (ACP) of fatty acid synthases, ACPs of polyketide synthases, the peptidyl carrier proteins (PCP), as well as aryl carrier proteins (ArCP) of nonribosomal peptide synthetases (NRPS). It is also present in formyltetrahydrofolate dehydrogenase. WebUsing Escherichia coli LipB as a model enzyme, we show here that the octanoyl-transferase mainly recognizes the 4'-phosphopantetheine-tethered acyl-chain of its donor substrate …

WebProtein knowledgebase. UniParc. Sequence archive. Help. Help pages, FAQs, UniProtKB manual, documents, news archive and Biocuration projects. UniRef. Sequence clusters. … WebAlthough holo-acyl carrier protein synthase, AcpS, a phosphopantetheinyl transferase (PPTase), was characterized in the 1960s, it was not until the publication of the landmark paper by Lambalot et al.in 1996 that PPTases garnered wide-spread attention being classified as a distinct enzyme superfamily.

WebJun 3, 2010 · Phosphopantetheine Adenylyltransferase from Mycobacterium tuberculosis in complex with 4'-phosphopantetheine. ... Find proteins for P9WPA5 (Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)) Explore P9WPA5 . Go to UniProtKB: P9WPA5. Entity Groups Sequence Clusters: WebPhosphopantetheine tethering is a posttranslational modification that takes place on the active site serine of carrier proteins 138 – ‘acyl carrier proteins (ACPs) and peptidyl …

WebJan 8, 2024 · 4'-Phosphopantetheine and long acyl chain-dependent interactions are integral to human mitochondrial acyl carrier protein function 4'-Phosphopantetheine and long acyl …

WebApr 26, 2024 · This protein belongs to the phosphopantetheine attachment site (IPR006162) and other protein classes of databases InterPro, pfam, and TIGRfam like srf AA. The genome also possesses gene srf AD (729 bp) encodes for the thioesterase domain-containing protein comprising 242 amino acids. drywall repair contractor clifton njWebProteomics of Streptococcus mutans to Reveal the Antibiofilm Formation Mechanism of Ag/ZnO Nanocomposites with Light-Emitting Diode Radiation commerce tx pay my billsWebOct 23, 2013 · The results suggest that some type I domains covalently incorporated in multidomain contexts possess potential protein binding sites missing in the equivalent regions of their respective structural templates. ... This 1136 residue long sequence is atypical since it does not possess a recognizable phosphopantetheine binding domain … drywall repair contractor brentwood tnWebphosphopantetheine-binding protein: copy AA seq copy Nt seq. PpisJ2_010100002376; WP_010369400.1; 206556 - 208052 (+) AMP-binding protein: copy AA seq copy Nt seq. PpisJ2_010100002381; WP_010369404.1; 208045 - 210228 (+) beta-ketoacyl-[acyl-carrier-protein] synthase family protein: copy AA seq commerce tx middle schoolWebPhosphopantetheine-binding site.: (A) Structural superposition of ATP-bound MsFadD32 and adenylate analog- and phosphopantetheine-bound PA1221 protein. The N- and C-terminal domains of... drywall repair contractor amarillo txWebJul 31, 2014 · Acyl carrier proteins (ACPs) are universal and highly conserved domains central to both fatty acid and polyketide biosynthesis. These proteins tether reactive acyl intermediates with a swinging 4′-phosphopantetheine (Ppant) arm and interact with a suite of catalytic partners during chain transport and elongation while stabilizing the growing … commerce tx to longview txWebOct 3, 2003 · is synthesized by the addition of cysteine to 4′-phosphopantothenate and, in the next step, P PC is decarboxylated to 4′-phosphopantetheine. 4′-phosphopantetheine is converted to coenzyme A by the enzymes 4′-phosphopantetheine adenylyltransferase and dephospho-CoA kinase ( Fig. 1 ). drywall repair contractor clinton township